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host-microbe interactions and immune receptor biology across the tree of life

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Author: Marc Nishimura

Posted on October 13, 2025October 13, 2025

Sorghum’s “evolutionary rescue” from global aphid outbreak was conferred by a non-canonical NLR locus.

Excited to see Carl VanGessel’s (Geoffery Morris lab) paper out in Science Advances!

These NLRs muct function via a novel mechanism as they lack both an N-terminal output domain and a functional p-loop ATP-binding motif?

Posted on September 12, 2025September 17, 2025

TIRome paper out in PNAS!

Adam, Lijiang, Mitchell, and colleagues used natural variation across ~150 Arabidopsis TIRs to help design artificial TIRs with predictable outputs.

https://doi.org/10.1073/pnas.2505893122

Posted on September 1, 2025September 17, 2025

First NIH award!

Phew! Very grateful to be awarded a MIRA for “Mechanisms of Toll/interleukin-1 receptor (TIR) domain function in cell death and immunity”. Awesome.

https://reporter.nih.gov/project-details/11089194

Posted on December 17, 2024September 17, 2025

Thomas Gagnier defends honor’s thesis and graduates!

Thomas defended his undgergraduate honor’s thesis for the Department of Biochemistry and Molecular Biology: “GENOME EDITING OF ENHANCED DISEASE SUSCEPTIBILITY1 USING CRISPR-CAS9 IN ARABIDOPSIS”. Worked closely with Sam and did a great job. Congratulations!

Posted on October 17, 2024September 17, 2025

Sam presenting at the 2024 Plant Adaptation Symposium at CSU

Posted on August 17, 2024September 17, 2025

2024 Summer meetings: Tyler and Sam presented at ASPB in Hawaii; Marc went to IPMB in Cairnes

Tyler stylishly presenting his thesis work on HopBA1.

Small, but definitely Sam!

Marc presented Adam’s TIRome story and explored Australian culture.

Posted on December 24, 2023September 17, 2025

Sam’s new review out in Current Opinion in Plant Biology

Sam’s new review with Dmity Lapin on TIRs and prospects for translation.

https://doi.org/10.1016/j.pbi.2023.102481

Features video interviews with Jonathan Jones and Jane Parker on emerging topics in plant immunity.

Posted on December 18, 2023September 17, 2025

2023 Fossil Ridge Genome Editing team presented at the STEM Academy celebration


Lily, Jay, Aiden, and Jaime presented their genome editing project at the final Fossil Ridge High School STEM Academy ceremony. Nice job, was fun to collaborate on this and have you in the lab!

Super fun to see all the great projects.

Posted on July 17, 2023September 17, 2025

2023 Summer Meetings: Marc invited to the VIII Simposio Brasileiro de Genetica Molecular de Plantas; Caio presented at MPMI Providence.

Great to see Zhiyong Wang and Paulo Teixeira!

Caio presenting his XopAZ RAZ1/RAZ2 story at MPMI Providence.

We also had a big Grangl reunion dinner, but managed to not take pictures?!

Posted on June 6, 2023September 17, 2025

Sam awarded a USDA-NIFA fellowship!

Sam was awarded a 3 year USDA-NIFA fellowship for his proposal “Investigating the role of monocot TIR proteins in plant-microbe interactions” Congrats Sam!

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