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host-microbe interactions and immune receptor biology across the tree of life

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Author: Marc Nishimura

Posted on June 6, 2023September 17, 2025

Sam awarded a USDA-NIFA fellowship!

Sam was awarded a 3 year USDA-NIFA fellowship for his proposal “Investigating the role of monocot TIR proteins in plant-microbe interactions” Congrats Sam!

Posted on March 17, 2023September 17, 2025

Adam and Sam’s new paper out in Science Advances!

Adam and Sam’s new paper explores how plant and prokaryotic TIR domains make an overlapping spectrum of small molecule products.

https://www.science.org/doi/10.1126/sciadv.ade8487

Posted on March 17, 2023September 17, 2025

Straight outta Brazil into a blizzard…

Caio Mendes from the Paulo Teixeira laboratory (University of Sao Paulo) is visiting the lab for 6 months to work on XopAZ1 and RAZ1/RAZ2 assay.

Welcome Caio, enjoy the snow!

Posted on October 17, 2022September 17, 2025

2022 Fossil Ridge HS Capstone Project team visits the lab

Keira and her Genetic Modification Team from Fossil Ridge High Schol visited the lab to work on their capstone project editing the Arabidopsis genome. Nice pipetting!

Posted on August 4, 2022September 17, 2025

Christopher and Adam at the 2022 CSU BMB REU poster session

Chris presented a poster on his collaboration with Adam engineering SPARTA as an artificial plant immune receptor.

Posted on July 17, 2022September 17, 2025

New TIR review out in Science with Kow et al.

Had fun writing this review on what we know about TIRs with Kow Essuman, Jeffery Milbrandt, and Jeff Dangl: “Shared TIR enzymatic functions regulate cell death and immunity across the tree of life“

https://www.science.org/doi/10.1126/science.abo0001

Posted on May 31, 2022July 5, 2022

Christopher Gomez joins lab for summer as an NSF-REU student!

Christopher Gomez (New Mexico State University) is joining the lab for the summer as an NSF-REU student. He’ll be working on engineering hybrid prokaryotic/plant immune receptors. Welcome Chris!

Posted on May 24, 2021June 22, 2021

Welcome to summer interns Mikayla Hart and Jedidiah Tulu!

We’re excited to have two undergraduate researchers with us for the summer. Mikayla (CSU, Biology) will work with Sam on HopBA1/ZAR1-related physical interactions, and Jed (CSU, Physics) is working with Adam to use machine learning to generate and test hypotheses about the function of the Arabidopsis TIRome.

Posted on January 1, 2021March 22, 2021

Tyler Todd joins the lab as a CMB MS student.

Tyler plans to expand on his projects started as an undergraduate in the lab, off to a great start!

Posted on June 5, 2020September 17, 2025

Adam’s 1st Nishimura lab paper!

Adam’s new review on TIR domain enzymatic function is out in the Frontiers in Genetics section on Evolution and Functional Mechanisms of Plant Disease Resistance.

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